You can help keep existing treatments working for longer

Thanks to your support, we’ve been able to make incredible progress in how we treat prostate cancer. For men with advanced prostate cancer, treatments like chemotherapy, radiotherapy, and hormone therapy can help keep the cancer under control. But there may come a time when they stop being effective. 

Treatment resistance can cut too many men’s lives short, and we can’t continue to let it happen. 

Will you help us make treatments more effective and for longer?

Yes, I'll help.

The drug that could keep treatments working effectively, and for longer

With your help, we’re funding research that can help us understand why hormone therapies like enzalutamide and abiraterone may stop working, so we can give men more time with their loved ones. 

Professor Johann de Bono at The Institute of Cancer Research, London, has conducted ground-breaking research that has already made a huge impact in the development of some of these drugs. Now, he’s leading a team of researchers to discover why these treatments become less effective. 

In men with prostate cancer, the disease can send out ‘SOS signals’ that encourage the immune system to protect the cancer cells instead of defending the body from them. These signals can stop treatments like enzalutamide and apalutamide from being effective.  

Prof de Bono and the team have been testing a new drug that stops immune cells picking up these SOS signals. That means both the immune system and our existing treatments can go back to doing their job – killing cancer cells.   

As part of our Transformational Impact Awards, we are now funding a clinical trial to prove that this new drug can help men with advanced prostate cancer benefit from treatments for longer – funding that’s available thanks to you. 

You can read more about his research here.

Will you help give men longer, better lives to be with their loved ones? 

Yes, I'll donate.

Danny’s story

Danny Burkey was diagnosed with incurable prostate cancer in June 2021 after experiencing some urinary problems. Over the years, he’s undergone various treatments, including chemotherapy, radiotherapy, and hormone therapy. 

But at the end of March 2025, he was told that the enzalutamide was no longer working.   

Danny says: “Since coming off the enzalutamide, I feel vulnerable. Unprotected against the cancer. It’s something that’s always at the back of my mind.”

Despite this, Danny thinks of himself as lucky. He has an amazing wife and three children who have supported him on his prostate cancer journey. And through his treatment – as well as his tireless campaigning for our work – he’s found a whole new community. 

By funding Prof de Bono’s research, you could put new drugs into the hands of the men who need them – men like Danny.

Please donate today.