Researcher - Dr Amanda Swain
Institution - Institute of Cancer Research
Grant award - £220,818
Duration - 2014-2017
Reference - PG13-019 Swain
Looking for genetic changes in men with prostate cancer that are able to drive the disease to a more aggressive stage.
Recent research has identified lots of genetic changes in men with prostate cancer. We now need to figure out which of these are the most important and will increase the risk of a man developing aggressive prostate cancer. The researchers have already carried out an experiment to identify mutations associated with aggressive disease in an animal model. They will compare this list to the list of mutations known to happen in men with prostate cancer and then check that the mutations they have selected are capable of driving prostate cancer to a more aggressive stage. Mutations in the genes identified could then be developed as biomarkers that would be able to predict how aggressive an individual’s cancer will be.