Enzalutamide is suitable for men with advanced prostate cancer that has stopped responding to other types of hormone therapy. You can have enzalutamide before or after chemotherapy.
Your hospital doctor may offer you enzalutamide if you can’t have chemotherapy, or you don’t want to have it yet. Enzalutamide may be suitable if your cancer isn’t causing any symptoms or only mild symptoms.
You may be offered enzalutamide if you’ve had chemotherapy with a drug called docetaxel, and your cancer has stopped responding to this treatment.
If you’ve already had a type of hormone therapy called abiraterone, enzalutamide probably won’t be an option. And if you’ve already had enzalutamide, abiraterone probably won’t be an option. This is because research suggests that men who have already had one of these drugs don’t respond so well to the other drug. However, if you get severe side effects from enzalutamide or abiraterone, you may be able to try the other drug.
If you’re having trouble getting enzalutamide, even though your doctor thinks it is suitable for you, please let us know.
Enzalutamide or abiraterone?
Enzalutamide and abiraterone are both types of hormone therapy that treat advanced prostate cancer.
Your hospital doctor will talk to you about which drug is most suitable for you. For example, enzalutamide may be a better option than abiraterone if your cancer has spread to the liver or lungs, or if you can’t take steroids. Abiraterone must be taken with a steroid.
But abiraterone may be a better option than enzalutamide if you’ve had:
- any falls
- any seizures (fits) or you have an increased risk of seizures
- extreme tiredness (fatigue)
- problems with memory or concentration.
This is because enzalutamide can increase your risk of these problems.
Some men may find enzalutamide easier to take because, unlike abiraterone, you don’t need to take it on an empty stomach and you don’t need to take steroids. But some men want to avoid the tiredness that enzalutamide can cause, and prefer to take abiraterone.
Speak to your doctor or specialist nurse about which treatments might be suitable for you and when to have them. You can also talk things through with our Specialist Nurses.