Showing 133 results

Can we exploit the unusual expression pattern of the ELF3 gene to treat advanced prostate cancer?

Funded research by Professor Norman Maitland of University of York into the study of ELF3 gene and its role in prostate cancer aggressiveness.

The role of Leukaemia Inhibitory Factor (LIF) in the spread of prostate cancer to bone

Funded research by Dr Claire Edwards of University of Oxford into understanding how prostate cancer spreads to the bone and find new therapies.

Developing new treatments to prevent the spread of prostate cancer cells

Funded research by Dr Andrew Chantry and Jessica Watt of the University of East Anglia into new ways to prevent the growth of prostate cancer.

Jason Webber

Sugar-coated proteins: a bitter cargo used by cancer cells to take hold, grow and spread

Funded research by Dr Jason Webber of Cardiff University which looks at identifying novel exosomal molecules essential for tumour growth, which are present in blood, as indicators of aggressive disease.

Using the pattern of genes expressed when oxygen levels in a tumour are low to identify patients who are less likely to benefit from radiotherapy

Funded research by Dr Ananya Choudhury of the University of Manchester which looks to identify patients with low oxygen (hypoxic) prostate cancers. This will allow doctors to select patients who are most likely to benefit from appropriate radiotherapy.

CogCan: understanding why thinking skills may change after androgen deprivation therapy for prostate cancer

Some men report changes in their thinking abilities after treatment with hormone therapy for their advanced prostate cancer. Now, we’re funding Professor Beth Grunfeld to conduct a clinical study to learn more about who these changes might affect, and why.

Dr Hayley Whitaker

Using imaging, blood and urinary biomarkers to improve the diagnosis of aggressive prostate cancer

Funded research by Dr Hayley Whitaker of University College London which aims to define which patients will benefit from diagnostic multiparametric (mp)MRI before biopsy and to improve the performance of the mpMRI itself.

Dr Dow-Mu Koh of Royal Marsden Hospital

Using whole body imaging to assess how well treatment is working for prostate cancer patients with bone metastases

Funded research by Dr Dow-Mu Koh of Royal Marsden Hospital which looks to test whether a technique called whole body diffusion weighted imaging is a reliable method of how well patients with advanced prostate cancer, who have been treated with olaparib, are responding to treatment.

Hing Leung

Investigation into whether we can control hormone resistant prostate cancer better by adding statins to traditional hormone treatment

Funded research by Professor Hing Leung of the University of Glasgow which looks at whether adding statins to hormone treatment will improve treatment response in hormone resistant disease, and whether any new tests can track how well the cancer is responding to treatment.

MULTIPROS: using imaging to improve prostate cancer diagnosis

Improved technology for imaging prostate cancer, like mpMRI, has helped transform diagnosis of the disease. Professor Nabi wants to add to the evidence that prostate imaging technologies should be made widely available to continue to improve diagnosis of the disease.

Justin Sturge

ENDOGLOW: Shining a light on early prostate cancer aggressiveness

Funded research by Dr Justin Sturge of Hull University to assess prostate cancer aggressiveness and give an early indication of whether treatment is necessary.

GAS5, a key regulator of advanced prostate cancer development and drug-resistance

Funded research by Prof. Gwyn Williams of Keele University into GAS5 and prostate cancer drug resistance.

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Understanding how the androgen receptor controls advanced prostate cancer development

Funded research by Dr Luke Gaughan of Newcastle University which looks to understand how different forms of the androgen receptor are regulated in advanced prostate cancer.

Jonathan Coulter

Damaging the cancer cell membrane using reactive oxygen species

Funded research by Dr Jonathan Coulter of Queens University Belfast investigating the use of a reactive oxygen species to damage the cancer cell membrane.

Finding metabolic target genes in prostate cancer

Turning microRNAs, a new type of genetic material, into a way to treat advanced prostate cancer

Joanne Edwards

New ways to treat advanced prostate cancer

Funded research by Dr Joanne Edwards of Glasgow University into new ways to treat advanced prostate cancer after hormone therapy stops working.

Anita Grigoriadis

Identify DNA markers to predict upgrading in men on active surveillance

Funded research by Dr Anita Grigoriadis of King's College London looking at finding DNA markers to identify men whose prostate cancer does not need treatment and can be managed by surveillance alone.

Alterations in a man's genetic make-up which lead to aggressive prostate cancer

Funded research by Prof. Rosalind Eeles and Dr Zsofia Kote-Jarai of the Institute of Cancer Research into genetic changes in the DNA repair genes and their relationship with aggressive disease.

Charlotte Bevan

Improving targeted therapy for men with prostate cancer

Funded research by Professor Charlotte Bevan of Imperial College London looking at improving targeted therapy for men with prostate cancer.

Dr Hayley Whitaker

Combining markers with imaging for improved diagnosis of aggressive prostate cancer

Funded research by Dr Hayley Whitaker of University College London looking at combining markers with imaging to improve the diagnosis and treatment of prostate cancer in a way that can easily be adopted by the NHS.

Matthew Lloyd

AMACR targeted drugs for treating advanced prostate cancer

Funded Research by Dr Matthew David Lloyd of University of Bath to discover new drugs to specifically block the function of a protein called AMACR, which is involved in prostate cancer growth

Nick Leslie

Making sure drugs hit the right targets in advanced prostate cancer

Research Funded by Dr Nicholas Leslie of Heriot Watt University investigating how loss of a gene called PTEN leads to aggressive prostate cancers.

Does virus infection play a role in the development of prostate cancer in men of African and African-Caribbean origin?

Funded Research by Professor Myra Olga McClure of Imperial College London which looked at whether a virus infection explains why some people of African and African-Caribbean origin are at greater risk of prostate cancer.

Transfer of human prostate cancer to mice for research into patient-specific therapy

Funded research by Dr Alastair Lamb of the University of Cambridge which will involve transferring human prostate cancer to mice to better understand how individual prostate cancers behave and which treatments they respond to.

Looking at legumain: a potential new treatment and route to immunotherapy

Funded research by Dr Rich Williams of Queen's University Belfast into how inhibiting Legumain may improve prognosis.