Institution - Institute of Cancer Therapeutics, University of Bradford
Researcher - Dr Klaus Pors
Grant award - £99,325
Duration - 2013-2016
Reference - S12-027 Pors
This project will look at expression of aldehyde dehydrogenase enzymes to find out how these enzymes are involved in the development of aggressive prostate cancer, and whether there is the potential to use any of these markers for the diagnosis of aggressive disease.
Advanced prostate cancer that no longer responds to hormone therapy is very difficult to treat, so we need to develop new treatment options. This project focuses on a set of enzymes called aldehyde dehydrogenases (ALDHs). Research suggests that there is a link between high levels of ALDH enzymes and cancer growth and spread (metastasis), but we don't know much yet about the underlying biology of this link. We hope that studying ALDHs and cancer growth will increase our understanding of the latter, so we will eventually be able to prevent it from happening.