This fact sheet is for men who have been offered radiotherapy to treat prostate cancer that has spread from the prostate to other parts of the body (advanced prostate cancer).
Last updated: March 2019 To be reviewed: June 2021
Bashir FA, Parry JM & Windsor PM. Use of a modified hemi-body irradiation technique for metastatic carcinoma of the prostate: Report of a 10-year experience. Clinical Oncology. 2008;20:591-598
British Uro-oncology Group (BUG), British Association of Urological Surgeons (BAUS), British Prostate Group (BPG). MDT (Multi-disciplinary Team) Guidance for managing prostate cancer. 2nd Edition. 2009
Chow E, Ling A, Davis L et al. Pain flare following external beam radiotherapy and meaningful change in pain scores in the treatment of bone metastases. Journal of the European Society for Therapeutic Radiology and Oncology 2005; 75/1: 64-9
Clarke N. Management of the spectrum of hormone refractory prostate cancer. European Urology. 2006;50:428-439
Din OS, Thanvi N, Ferguson CJ, Kirkbride P. Palliative radiotherapy for symptomatic advanced prostate cancer. Radiotherapy and Oncology. 2009;93:192-196
Finlay IG, Mason M D & Shelley M. Radioisotopes for the palliation of metastatic bone cancer: a systematic review. Lancet Oncology 2005;6:392–400
GE Healthcare. Metastron (Strontium-89 chloride injection). 2006
Hird A, Chow E, Zhang L, et al. Determining the incidence of pain flare following palliative radiotherapy for symptomatic bone metastases: results from three canadian cancer centers. In J Radi Oncol Biol Phys. 2009; 75(1):193-7
Jager PL. Treatment with radioactive strontium for patients with bone metastases from prostate cancer. BJU International 2000; 86: 929-934
James ND, Bloomfield D, Luscombe C. The changing pattern of management for hormone-refractory, metastatic prostate cancer: Review.
Li KK, Hadi S, Kirou-Mauro A et al. When should we define the response rates in the treatment of bone metastases by palliative radiotherapy? Clinical Oncology (Royal College of Radiologists). 2008;20(1):83-9
Loblaw DA, Wu JS, Jackson S, Kirkbride P. Pain flare in patients with bone metastases after palliative radiotherapy--a nested randomized control trial. Supportive Care in Cancer. 2007;15(4):451-5
Lutz S, Berk L, Chang E, et al. Palliative radiotherapy for bone metastases: An ASTRO evidence-based guideline. Int. J. Radiation Oncology Biol. Phys. 2011;79
National Institute for Health and Clinical Excellence, Prostate Cancer: diagnosis and treatment (Full guidance). February 2008
Notes for Guidance on the Clinical Administration of Radiopharmaceuticals and Use of Sealed Radioactive Sources. Administration of Radioactive Substances Advisory Committee 2006. Revised 2011.
Oosterhof GON, Roberts JT, de Reijke Th.M, et al. Strontium89 Chloride versus Palliative Local Field Radiotherapy in Patients with Hormonal Escaped Prostate Cancer: A Phase II Studyof the European Organisation for Research andTreatment of Cancer Genitourinary Group. European Urology. 44 (2003) 519–526
Prostate Cancer and Prostatic Diseases2006; 9: 221-229
The British Pain Society. Cancer Pain Management. A perspective from the British Pain Society, supported by the Association for Palliative Medicine and the Royal College of General Practitioners. January 2010.
This fact sheet is for people who have been diagnosed with advanced (metastatic) prostate cancer - cancer that has spread from the prostate to other parts of the body. It explains what advanced prostate cancer is, what your test results mean, and the treatments available.
This booklet is for men who have prostate cancer that has spread to other parts of the body (advanced prostate cancer) and who have symptoms such as fatigue or bone pain. We describe the symptoms you might get and the treatments available to help manage them.