This fact sheet is for men with advanced (metastatic) prostate cancer that has spread to the bones. We explain what metastatic spinal cord compression (MSCC) is, what symptoms to look out for, and how MSCC is treated.

Last updated: February 2019
To be reviewed: February 2022


Updated: February 2019 | Due for Review: February 2022

  • Al-Qurainy R, Collis E. Metastatic spinal cord compression: diagnosis and management. BMJ. 2016 May 19;353:i2539.
  • Crnalic S, Hildingsson C, Bergh A, Widmark A, Svensson O, Löfvenberg R. Early diagnosis and treatment is crucial for neurological recovery after surgery for metastatic spinal cord compression in prostate cancer. Acta Oncol Stockh Swed. 2013 May;52(4):809–15.
  • George R, Jeba J, Ramkumar G, Chacko AG, Tharyan P. Interventions for the treatment of metastatic extradural spinal cord compression in adults. In: The Cochrane Collaboration, editor. Cochrane Database of Systematic Reviews [Internet]. Chichester, UK: John Wiley & Sons, Ltd; 2015 [cited 2016 Apr 13]. Available from:
  • Husband DJ. Malignant spinal cord compression: prospective study of delays in referral and treatment. BMJ. 1998 Jul 4;317(7150):18–21.
  • Husson O, Mols F, Poll-Franse LV van de. The relation between information provision and health-related quality of life, anxiety and depression among cancer survivors: a systematic review. Ann Oncol. 2010 Sep 24;mdq413.
  • Loblaw DA, Mitera G, Ford M, Laperriere NJ. A 2011 updated systematic review and clinical practice guideline for the management of malignant extradural spinal cord compression. Int J Radiat Oncol. 2012;84(2):312–7.
  • Mottet N, Van den Bergh RCN, Briers E, Bourke L, Cornford P, De Santis M, et al. EAU - ESTRO - ESUR - SIOG Guidelines on Prostate Cancer. European Association of Urology; 2018.
  • National Collaborating Centre for Cancer. Metastatic spinal cord compression: diagnosis and management of patients at risk of or with metastatic spinal cord compression. 2008.
  • National Institute for Health and Care Excellence (NICE). Metastatic spinal cord compression in adults - quality standard 56. 2014.
  • National Institute for Health and Care Excellence. Metastatic spinal cord compression: Diagnosis and management of adults at risk of and with metastatic spinal cord compression. NICE clinical guideline 75 [Internet]. 2008. Available from:
  • Pettersson A, Johansson B, Persson C, Berglund A, Turesson I. Effects of a dietary intervention on acute gastrointestinal side effects and other aspects of health-related quality of life: A randomized controlled trial in prostate cancer patients undergoing radiotherapy. Radiother Oncol. 2012 Jun;103(3):333–40.
  • Samphao S, Eremin JM, Eremin O. Oncological emergencies: clinical importance and principles of management. Eur J Cancer Care (Engl). 2010;19(6):707–13.
  • Steinberg M. Degarelix: A gonadotropin-releasing hormone antagonist for the management of prostate cancer. Clin Ther. 2009 Jan;31:2312–31.

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