1. Cardiovascular risks are a better indicator of high-grade prostate cancer than metabolic syndrome
Evaluating Metabolic Syndrome (MS) as a single condition may be an inappropriate approach to investigating prostate cancer risk. This study aimed to evaluate the strength of association between individual cardiovascular risks (CVR) and prostate cancer diagnosis at biopsy by correlating the histological characteristics (Gleason score) with the grading of CVR. This may be a more appropriate method to define the metabolic profile of patients since CVR status includes several possible risk factors such as age, smoking status and personal and family history of renal/cardiovascular disease, which are not included in the definition of MS. According to the study by Nunzio et al, moderate/high CVR was associated with a 2.5 times increased risk of high-grade prostate cancer. Further studies in a large patient population across multiple institutions and countries are needed to confirm the results of the research and to better understand which molecular pathway is responsible for the observed results.