Studying the role the GNMT protein plays in prostate cancer

Imperial College LondonDr Lakjaya Buluwela£102,2202008 - 2011

Why we funded it

With a previous grant from The Prostate Cancer Charity Dr Buluwela identified a new protein that may be playing a very important role in prostate cancer. This new project will determine what role this protein is playing and how it works. The project will provide valuable knowledge about how prostate cancer works and validate a new target for future prostate cancer inventions.

Scientific title: Androgen regulation of methylation in prostate cancer.

Research project summary

Androgens, the male sex hormones, regulate the healthy prostate. Androgens will also encourage prostate cancer cells to grow and multiply. With a previous grant from The Prostate Cancer Charity Dr Buluwela identified several hundred genes in prostate cells that are controlled by androgens. They found that the Glycine N-methyltransferase (GNMT) gene is highly affected by the presence of androgens. Dr Buluwela's previous work also suggests that GNMT plays a central role in prostate cancer. In this project a PhD student will investigate what role the GNMT protein plays in prostate cancer cells.