Investigation of a new target for the prevention of prostate cancer spreading to bone : The role of Endo180 in prostate cancer cell migration and metastasis

Imperial College, Department of Oncology, Hammersmith CampusDr Justin Sturge£97,0932007 - 2010

Why we funded it

A major clinical complication in both younger and older men with advanced prostate cancer is the danger of cancer spreading to the bone. The results of these studies will help determine whether targeting Endo180 in men with prostate cancer could help prevent spread of their disease to bone, greatly improving and extending the lives of men with prostate cancer.

Scientific title

The role of Endo180 in prostate cancer cell migration and metastasis.

Research project summary

Secondary tumours in the bone occur when cancerous cells move from the prostate gland. Certain molecules help this process and are good targets for preventative treatment. Dr Sturge's work in breast cancer revealed that Endo180 can help cells from breast tumours spread to secondary sites and antibodies targeted against Endo180 stopped this cell movement. Endo 180 in breast cancer was described as the 'Pied Piper' of breast cancer because of the way it helped cells spread from one place to another. Similarly, this research will investigate the role of the Endo180 molecule in promoting the spread of prostate cancer.