Pre-clinical models of prostate cancer

University of LeedsProfessor Terence Rabbitts£245.7612010 - 2013

Why we funded it

This study is a basic study of the role and inter-relationships of genetic changes in prostate cancer. The study is aimed to better define prostate specific gene mutations and study the development of the disease. There are no models of human cancer and our unique technology will provide a pre-clinical model for distribution to laboratories involved in anti-prostate drug development. New drugs will be tested using a mouse model that will be the best mimic possible to the disease in men. This is vital to form the basis of drug development for treatment of prostate cancer in men, with particular emphasis of advanced, hormone-resistant disease.

Scientific title

Mouse modelling of prostate cancer through TMP-ETS family fusion genes.

Research project summary

Mouse models of cancer have already been invaluable in understanding human cancer development and in developing new drugs.  For prostate cancer, there is as yet no mouse model that replicates the human disease entirely, for example by originating from a single cell in the prostate and from the same genetic mutations.  This project is aimed at generating such a model.

The team in Leeds have developed a unique genetic manipulation technology that will be used to make mice that develop prostate cancer in a much more human-like way.  This will provide the prostate cancer research community an excellent tool for testing new drugs or combinations of drugs before they are launched into trials in people.  It will also give new insight into the crucial genetic changes that underlie human prostate cancer development and progression.