Why we funded it
The MEK5/ERK5 proteins are important for messaging within normal
cells but abnormally high levels of MEK5 and ERK5 proteins are
present in prostate cancer cells. This abnormal expression is
strongly associated with aggressive cancer and reduced patient
survival time. Medicines that influence the way MEK5/ERK5 work may
have important benefits as clinical treatment, and may even have
implications for other cancer types.
Scientific title
Validation of the MEK5/ERK5 pathway as a target for therapy in
prostate cancer.
Research project summary
Professor Leung's team are going to investigate the
MEK5/ERK5 signalling pathway inside cells. The research will look
at how this pathway contributes to cancer development, and whether
it could act as a potential target for prostate cancer
treatment.