What is PIN?
Dickinson SI. Premalignant and malignant prostate lesions:
pathologic review. Cancer Control 2010, 17(4):214-22.
Zynger, D L and Yang, X. High-grade Prostatic Intraepithelial
Neoplasia of the Prostate: The Precursor Lesion of Prostate Cancer
(Review). Int J Clin Exp Pathol. 2009, 2(4) 327-338
Am I more likely to get prostate cancer if I have
PIN?
De Nunzio C, Trucchi A, Miano R, Stoppacciaro A, Fattahi H,
Cicione A, Tubaro A. The number of cores positive for high grade
prostatic intraepithelial neoplasia on initial biopsy is associated
with prostate cancer on second biopsy. J Urol. 2009,
181(3):1069-74.
Epstein JI, Herawi M. J Prostate needle biopsies
containing prostatic intraepithelial neoplasia or atypical foci
suspicious for carcinoma: implications for patient care. Urol. 2006
Mar;175(3 Pt 1):820-34.
Lee MC, Moussa AS, Yu C, Kattan MW, Magi-Galluzzi C, Jones JS.
Multifocal high grade prostatic intraepithelial neoplasia is a risk
factor for subsequent prostate cancer. J Urol. 2010,
184(5):1958-62.
Merrimen JL, Jones G, Srigley JR. Is high grade prostatic
intraepithelial neoplasia still a risk factor for adenocarcinoma in
the era of extended biopsy sampling? (2010). Pathology 2010,
42(4):325-9.
Merrimen JL, Jones G, Walker D, Leung CS, Kapusta LR, Srigley
JR. Multifocal high grade prostatic intraepithelial neoplasia is a
significant risk factor for prostatic adenocarcinoma. J Urol. 2009,
182(2):485-90.
Zynger, D L and Yang, X. High-grade Prostatic Intraepithelial
Neoplasia of the Prostate: The Precursor Lesion of Prostate Cancer
(Review). Int J Clin Exp Pathol. 2009, 2(4) 327-338
How common is PIN?
Zynger, D L and Yang, X. High-grade Prostatic Intraepithelial
Neoplasia of the Prostate: The Precursor Lesion of Prostate Cancer
(Review). Int J Clin Exp Pathol. 2009, 2(4) 327-338
Will I need treatment or follow up tests?
Price et al Toremifene for the prevention of prostate cancer in
men with high grade PIN: results of a double-blind, placebo
controlled, phase IIB clinical trial. J Urol 2006;
176:965-970
Thompson et al. Finasteride decreases the risk of PIN. J Urol
2007; 178: 107-109
Zanardi S, Puntoni M, Maffezzini M, Bandelloni R, Mori M,
Argusti A, Campodonico F, Turbino L, Branchi D, Montironi R,
Decensi A. Phase I-II trial of weekly bicalutamide in men with
elevated prostate-specific antigen and negative prostate biopsies.
Cancer Prev Res (Phila), 2009; 2(4):377-84.
Zynger, D L and Yang, X. High-grade Prostatic Intraepithelial
Neoplasia of the Prostate: The Precursor Lesion of Prostate Cancer
(Review). Int J Clin Exp Pathol. 2009, 2(4) 327-338