Prostate and prostate cancer FAQs

Our Specialist Nurses receive thousands of emails and phone calls each year from men, their families and friends and health professionals asking for information about prostate cancer. The following pages give answers to some of the most common questions we receive.

If you would like to contact our confidential helpline, you can call 0800 074 8383 or fill in our email contact form.

Please note responses are based on UK practice. We hope this information will add to the medical advice you have had. Please do continue to talk to your doctor if you are worried about any medical issues.

Contents

 

Problems with my prostate

What does 'benign enlargement of the prostate' mean?

Benign prostatic enlargement (BPE) is the medical term used to describe an enlarged prostate. It means a non-cancerous enlargement of the prostate gland.

You might also hear it called benign prostatic hyperplasia (BPH). Hyperplasia means an increase in the number of cells. It's this increase in cells that causes the prostate to grow.

An enlarged prostate is common for men after the age of about 50. About 4 out of every 10 men (40 per cent)1 over the age of 50 and 3 out of 4 men (75 per cent)2 in their 70s have urinary symptoms that are caused by an enlarged prostate.

Normal And Enlarged Prostate

Having an enlarged prostate is not the same as having cancer.

Read more about the symptoms, diagnosis and treatment of an enlarged prostate.

Last updated: January 2013

To be reviewed: January 2015

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Risk factors

Am I more likely to get prostate cancer if my father had it?

Inside every cell of our body is a set of instructions called genes. These are inherited from our parents. Genes control how the body grows, works and what it looks like. Researchers have found some characteristics in genes that might be passed on through your parents and could increase your risk of developing prostate cancer.1  Only 5 to 10 per cent of prostate cancers are thought to be strongly linked to an inherited risk.2

  • You are two and a half times more likely to get prostate cancer if your father or brother has been diagnosed with it, compared with a man who has no affected relatives.3
  • There may be a higher chance of you developing prostate cancer if your relative was under 60 when he was diagnosed or if you have more than one close relative with prostate cancer.3

Last updated January 2013

To be reviewed January 2015

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Is it true that African Caribbean men are more likely to get prostate cancer?

In the UK, African Caribbean men are three times more likely to develop prostate cancer than white men of the same age1. The reasons for this increased risk are not yet clear but may be due to changes in their genes passed down through generations.2-6

You can read more online or download our leaflet, What do you know about your prostate? Information for African Caribbean men.

Last updated May 2011

To be reviewed May 2013

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Is there anything I can do to prevent getting prostate cancer?

We don't know how to prevent prostate cancer for certain, but a healthy diet and lifestyle may be important. Eating healthily and being active can help you stay a healthy weight. This may mean that you are less likely to be diagnosed with aggressive1  or advanced2-4 prostate cancer. A healthy lifestyle can also improve your general wellbeing and reduce your risk of other health problems such as diabetes, heart disease and some other cancers.5

Read our pages on diet and your risk of prostate cancer for more information.

Last updated December 2012

To be reviewed December 2014

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Diet

Do vitamin E and selenium protect against prostate cancer?

Vitamin E

Previous research suggested that vitamin E supplements might help prevent prostate cancer and help protect against advanced cancer. More recent research has shown that it does not have this effect and might even be harmful1.  You do need vitamin E in your diet; like all vitamins it is vital for good health. The best way to get enough vitamin E is through a balanced diet, without taking supplements.

Selenium

There is evidence to suggest that selenium helps to protect against prostate cancer2,3 and advanced prostate cancer.2 Most of us in the UK don't have much selenium in our diet, but some foods are a good source of it. These include Brazil nuts, fish, seafood, liver, kidney and poultry. Taking selenium supplements doesn't appear to have any benefit in protecting against prostate cancer.2,3

Please visit our pages diet and prostate cancer for more information on improving your diet.

Last updated December 2012

To be reviewed December 2014

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Does drinking alcohol increase my risk of getting prostate cancer?

We don't know if alcohol has any specific effects on men with prostate cancer. But we do know that drinking too much alcohol can make you put on weight and causes health problems such as heart disease and some other cancers.1

The government advises that men should not regularly drink more than three to four units of alcohol a day.2

How many units are in a drink?

  • A pint of lager, beer or cider contains 2.8 units
  • A 175ml glass of wine contains 2.1 units
  • A 25ml measure of 40 per cent single spirit with mixer contains 1 unit

Your doctor or nurse can tell you whether alcohol will affect your prostate cancer treatment. If you have urinary problems after treatment, try to cut down on alcohol as it can irritate the bladder and make the problems worse. You can find out more about managing how much you drink from NHS Choices.

Last updated December 2012

To be reviewed December 2014

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Does red wine help to prevent prostate cancer?

Red wine contains natural compounds called antioxidants that may help prevent damage to cells. Antioxidants are found in the skin and seeds of grapes as well as other fruits and vegetables. Red wine contains more antioxidants than white wine because it is made with grape skin but white wine is not.

In 2005, one small study found that red wine may help to lower a man's risk of prostate cancer1. However, since then larger studies have not found this to be true2,3. Therefore there is not enough evidence at present to say that red wine helps to prevent prostate cancer.

Drinking a lot alcohol might increase your risk of prostate cancer4,5. Drinking alcohol also increases your risk of some other cancers and health problems such as high blood pressure and stroke6-8. If you are drinking alcohol, you should aim to stay within the recommended limits for your general health6-8. If you would like to know more about how diet may affect your risk of prostate cancer, read our pages about healthy living.

Last updated December 2012

To be reviewed December 2014

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Screening

Why is there no screening programme for prostate cancer?

Screening programmes aim to spot the early signs of cancers in people who do not have any symptoms. In the UK there are screening programmes for breast, cervical and bowel cancer.

There is currently no screening programme for prostate cancer. One reason for this is that the PSA test is not reliable enough to be used as part of a screening programme. Read about the advantages and disadvantages of the PSA test.

Some studies show that screening using the PSA test could reduce the number of deaths from agressive prostate cancer but it could also increase the number of men having unnecessary treatment for slow growing prostate cancer.

In most cases prostate cancer is slow growing and may not cause any problems in a man's lifetime.1  However, some men will have fast growing cancer that needs treatment to delay or prevent it spreading outside of the prostate gland.

At the moment, if you are diagnosed with prostate cancer, there is no way to tell whether it will be fast or slow growing, so many men will have treatment. Treatment can cause significant side effects such as erectile dysfunction and urinary problems. So, screening could lead to many men having worse side effects from treatment than they would have had from the cancer itself.

Although there is currently no screening programme for all men, research is looking into how screening could be used to target men who have a higher risk of prostate cancer due to genes passed down in their families. Early results suggest that regular PSA tests could be helpful for these men, but we still need more information.2  Only a small number of prostate cancers are thought to be linked to genes. But if you have a strong family history you may want to discuss this with your GP. Read more on family history and prostate cancer.

If you are concerned about prostate cancer, you can talk to your GP about your individual risk and talk through the advantages and disadvantages of the PSA test. If you then decide that you want a PSA test, you can ask your GP for one.

Researchers have been looking at other tests that may be more helpful in diagnosing prostate cancer. These tests are not widely available but they include the following. Find out more here.

Last updated July 2012

To be reviewed July 2014

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Diagnosis 

What is the PCA3 test?

Researchers have been looking at a number of other tests that may be helpful in diagnosing prostate cancer. These tests are not widely available and more research is needed before we can be sure how useful they are.

The PCA3 test is a urine test. Your doctor or nurse will massage your prostate and then take a urine sample. Cells from the prostate pass into the urine where they can be examined later with a special genetic-based test. The PCA3 test might be useful in helping to decide whether some men who have had PSA test should have a biopsy.1  Or for monitoring men who have already had prostate biopsies and no cancer was found.2  This test is not usually available on the NHS as more clinical trials are needed first.3

Read more about the tests to diagnose prostate cancer.

Last updated March 2012

To be reviewed March 2014

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What does 'Gleason score' mean?

If your biopsy samples contain cancer, it is graded to show how active the cancer is. The pathologist looks at the pattern made by the cancer cells and gives that pattern a grade from 1 to 5. This is called Gleason grading.

Gleason score

The pathologist may see more than one grade of cancer in the biopsy samples. The grades of the most common pattern and the pattern with the highest grade are added together to give a 'Gleason score'.   
For example, if the biopsy shows that most of the cancer seen is grade 3 and the highest grade of cancer seen is grade 4, the Gleason will be 3+4, and the Gleason score will be 7.

The higher the Gleason score, the more aggressive the cancer and the more likely it is to spread. Gleason scores run from 2 to 10. However, today doctors usually only give a Gleason grade of 3 or more, so your Gleason score will normally be between 6 and 10.1

It is important to remember that your Gleason score is one of a few factors that helps give your doctor an overall idea of your cancer. They will also need to look at your PSA result and how far your cancer has spread (stage).

Read more about Gleason grading.

Last updated March 2012

To be reviewed March 2014

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What is the 'stage' of my cancer and what does this mean?

Staging is a way of recording how far the cancer has spread. The most common method is the TNM (Tumour-Nodes- Metastases)system. This system separately assesses the tumour (T), lymph nodes (N) and secondary cancer or metastases (M).

Read more about staging.

Last updated March 2012

To be reviewed March 2014

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Treatment

What is a multi-disciplinary team (MDT)?

This is the team of health professionals or specialists involved in your care. The team may include:

  • A consultant urologist: This is a doctor who specialised in the urinary and reproductive systems. Urologists are also surgeons.
  • A consultant oncologist: This is a doctor who specialised in cancer treatments other than surgery, for example radiotherapy.
  • A consultant radiologist: This is a doctor who specialises in diagnosing medical conditions using X-rays and scans.
  • A consultant pathologist (also known as a histopathologist): This is a doctor who specialised in studying cells and tissues under the microscope to identify diseases. A pathologist will examine biopsy samples to diagnose prostate cancer.
  • A clinical nurse specialist:This is a nurse who specialises in a particular medical condition. They are also sometimes known as key workers.
  • A key worker: This is your main point of contact: This is usually your specialist nurse but may be another member of the multi-disciplinary team. They help to coordinate your care and can guide you to the appropriate team member or sources of information.

Last updated July 2012

To be reviewed July 2014

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How will I know my cancer is spreading if I am having active surveillance?

Active surveillance involves monitoring your prostate cancer with regular tests, rather than treating it straight away. The tests aim to find any changes that suggest the cancer is growing. If any important changes are found then treatment can be offered at an early stage, with the aim of getting rid of the cancer completely.

Monitoring varies from hospital to hospital but if you choose active surveillance, you will have the tests listed below.

Prostate specific antigen (PSA) tests
You will have these every three to six months. This measures the amount of PSA in your blood. PSA is a protein produced by cells in the prostate.

Digital rectal examinations (DRE)
You will have these every three to six months for two years, then every year. A DRE is where a doctor or nurse feels your prostate gland through the wall of your back passage (rectum).

Prostate biopsies
You will normally have these every few years, depending on your treatment centre.1  A biopsy involves taking small pieces of prostate tissue to look at more closely under a microscope for signs of prostate cancer. This will be like the biopsy you had when your cancer was first found. You may hear this called a trans-rectal ultrasound (TRUS) guided prostate needle biopsy.

Read more about the tests to diagnose prostate cancer.

The tests aim to find any changes that suggest that the cancer is growing. Treatment can then be offered at an early stage, with the aim of getting rid of the cancer completely.

For further information, please read our page on active surveillance.

Updated June 2012

To be reviewed June 2014

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Should I have surgery or radiotherapy?

There may be more than one treatment that is suitable for you. Your choice of treatment will depend on your test results, personal preferences and a number of other factors.

Surgery (radical prostatectomy)

  • This is an operation to remove the whole prostate gland. There are several types of operation: laparoscopic (keyhole) surgery
  • traditional open surgery, and
  • robotic-assisted keyhole surgery.


You can read more about radical prostatectomy, the different types of operation and possible side effects in our pages about surgery.


External beam radiotherapy (EBRT)

This treatment uses high energy X-ray beams to destroy the cancer cells. The X-ray beams are directed at the prostate from outside the body.

You may be offered hormone therapy for several months before starting radiotherapy. This is to shrink the prostate and help make the treatment more effective. In some cases you may continue hormone therapy for two to three years after radiotherapy.

For more information about EBRT, including the possible side effects, read our pages about external beam radiotherapy.

Updated July 2012

To be reviewed July 2014

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Is robotic surgery better than surgery by hand?

Robot-assisted surgery to remove your prostate is relatively new and is only available in some hospitals in the UK. If your hospital does not carry out robot-assisted surgery, they may be able to refer you to one that does.

All types of surgery appear to be as good as each other in treating prostate cancer1  and have similar side effects. Your doctor or nurse can tell you which types of operation are available in your area.

For further information please read our pages about surgery.

Updated August 2012

To be reviewed August 2014

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How can I find out if my consultant is a good surgeon?

The most common side effects of surgery for prostate cancer are difficulty getting and keeping an erection (erectile dysfunction) and leaking urine (urinary incontinence). The risk of getting these side effects depends on your overall health, the stage and grade of your cancer and also your surgeon's skill and experience.

Your surgeon should be able to give you information about how many operations they have done, the outcomes of these and the rate of side effects. Research suggests that surgeons who do at least 20 radical prostatectomies each year, and ideally more than 35 a year, have better results, including lower rates of side effects.1   Hospitals should carry out more than 50 radical operations for prostate or bladder cancer in a year.2

If you are worried, ask your surgeon:

•    How many of these operations have you done and how many do you do each year?

For more information please read our pages about surgery.

Last updated September 2012

To be reviewed September 2014

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How do oestrogens treat prostate cancer?

You may be given oestrogen to treat your prostate cancer if your original hormone therapy stops working. Diethylstilbestrol (Stilboestrol®) is a tablet that is similar to the hormone oestrogen. Oestrogen is a hormone found in both men and women, but women usually produce more. Diethylstilbestrol can be used to treat prostate cancer that is no longer responding to other types of hormone therapy.

Diethylstilbestrol can cause similar side effects to other types of hormone therapy, such as breast swelling and tenderness. A low dose of radiotherapy to the breast area can prevent this. You can read more about this and other side effects in our booklet, Living with hormone therapy: A guide for men with prostate cancer.

Diethylstilbestrol can also increase your risk of circulation problems, such as blood clots.1  You will usually take drugs such as aspirin or warfarin to reduce the risk of blood clots.2  You may not be able to take diesthylstilbestrol if you have a history of high blood pressure, heart disease or strokes. Your doctor or nurse will discuss this with you and can explain the risks and benefits.

Last updated October 2012

To be reviewed October 2014

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What is abiraterone?

Abiraterone (Zytiga®) is a new type of hormone therapy for men with advanced prostate cancer that has stopped responding to other hormone therapy. It is suitable for men who have already had docetaxel chemotherapy and whose cancer has started to grow again. Abiraterone may help some men to live longer.1  It can also help control symptoms.

Abiraterone is taken as a tablet and works by stopping the production of testosterone. You will also take a steroid called prednisone to reduce the risk of side effects. Side effects of abiraterone include fluid retention, high blood pressure, liver problems and a lower than normal level of potassium in the blood.2  This could make you feel tired and you may be a risk of a fast irregular heartbeat. You should contact your doctor if you experience this. You will have your blood pressure checked regularly, and have blood tests to check how well your liver is working.

Abiraterone is also effective in men who have stopped responding to other types of hormone therapy but have not yet had chemotherapy.3  However it is not widely available in the UK for these men. If your doctor thinks it is suitable for you, they may be able to apply for you to get it.

Last updated October 2012

To be reviewed October 2014

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Side effects

How can I get an erection after treatment?

Some treatments for prostate cancer can damage the nerves and blood vessels that are needed for an erection. Treatments that can have this effect include surgery, external beam radiotherapy, brachytherapy, high intensity focused ultrasound (HIFU) and cryotherapy.

All types of hormone therapy can cause erection problems because hormone therapy can reduce your desire for sex (libido).1 

Many of the treatments for erection problems work by improving the flow of blood to the penis.

The treatments are:

  • tablets
  • injections
  • pellets
  • vacuum pump
  • surgical implant
  • sex therapy.

Because getting an erection also relies on your thoughts and feelings, a combined approach to erection problems often works well.2-4 Try getting some medical treatment as well as tackling any worries or relationship issues you may have. There are lots of ways to do this, so pick what works best for you. It may be talking to someone close to you, seeing your nurse or getting some counselling or sex therapy.

Read our information about sex and prostate cancer to find out more about treatments for erections problems.

Last updated December 2012

To be reviewed December 2014

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When will I stop leaking urine after surgery?

Surgery may weaken some of the muscles and damage nerves that help you control passing urine. This can cause you to leak urine. You may leak a few drops when you exercise, cough or sneeze (stress incontinence). Some men may leak larger amounts of urine and need to wear absorbent pads or pants, especially in the weeks after the operation. The risk of urinary problems will also depend on other factors such as your age.

You may continue to leak urine for several months after surgery.1 This is usual. Pelvic floor muscle exercises may help you regain control of your bladder more quickly after surgery. 2,3   You may need to practise the exercises for up to three to six months after your operation before you see an improvement in your symptoms.  And you may find it helps to continue doing pelvic floor muscle exercises regularly. For more information about pelvic floor muscle exercises and how to do them, read our Tool Kit fact sheet, Pelvic floor muscle exercises [PDF].

Urinary symptoms should improve with time and most men will notice an improvement three to six months after surgery. However, some men may still have problems with leaking urine a year after having surgery.

There are treatments available that can help manage urinary problems, as well as things that you can do yourself. You can read more about these in our Tool Kit fact sheet, Urinary problems and prostate cancer. You can also call our Specialist Nurses on our confidential helpline.

Last updated August 2012

To be reviewed August 2014

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Does stopping hormone therapy from time to time help to reduce the side effects?

Some doctors believe that intermittent hormone therapy can be as good as continuous hormone therapy at controlling prostate cancer. This involves stopping treatment when your PSA level is low and steady and starting treatment again when your PSA starts to rise. This process is repeated for as long as it continues to work. Your doctor or nurse will advise you on when you will stop and start treatment.

The advantage of intermittent hormone therapy is that you may be able to avoid side effects during the time that you are not having treatment. However, it can take three to nine months, or sometimes longer, for the side effects to wear off.  Researchers think that intermittent hormone therapy may be just as effective at treating prostate cancer as continuous treatment, but this is still being tested in clinical trials.1 We do not yet fully understand all of the benefits and risks of intermittent hormone therapy and it may not be suitable for all men.

Last updated May 2011

To be reviewed May 2013

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How can I manage hot flushes?

Hot flushes are a common side effect of hormone therapy.1  They give you a sudden feeling of warmth in the upper body and can be similar to those experienced by women going through the menopause.

There are a number of different options to help you manage hot flushes, including lifestyle changes, drug treatments and complementary therapies. Find out more about managing hot flushes in our pages about the side effects of hormone therapy.

Last updated May 2011

To be reviewed May 2013

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Why do I feel so low now that I'm having hormone therapy?

The side effects of hormone therapy can be difficult to cope with. Some men find that the physical change to their bodies, such as putting on weight, or changes to their sexual function, can make them feel very different about their bodies and cause a sense of loss. Sometimes men describe feeling less masculine as a result of their diagnosis and treatment.

Changes to your daily life that may happen when you are on hormone therapy can also cause a sense of loss. For example, your role within your relationship may be different to how it was before, or you may feel too tired to do some of the things you used to do. Hormone therapy may also affect your mood. You may find that you feel more emotional than usual or just 'different' to how you felt before. Some men may also experience low moods or depression. This can be as a direct result of hormone therapy, a response to the shock of diagnosis or the impact that treatment can have on your life.

Sharing your feelings can help you to cope with them. Your doctor and specialist nurse can answer any questions you may have and may be a good source of support. You may also find it helpful to talk to your partner, close friends and family, or to a counsellor.

Prostate Cancer UK offers a free and confidential helpline where you can speak to one of our Specialist Nurses about your problems. We can also provide one to one peer support with a volunteer. To find out about support groups in your local area, click here.

Last updated May 2011

To be reviewed May 2013

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Can I have side effects from radiotherapy four years after treatment?

Like all treatments, radiotherapy has side effects. Most short term side effects will settle down after your radiotherapy treatment has finished. But you can have later side effects that develop several months, or even years, after you finish your treatment. These side effects can be long term. They include loose stools, pain around the abdomen and bleeding from the back passage. For a full list of symptoms, read our pages about radiotherapy.


Older age, diabetes, previous bowel or prostate surgery, and previous bladder and bowel problems can all increase your risk of getting long term side effects. Speak to your doctor or nurse about your own risk.

Last updated July 2012

To be reviewed July 2014

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Lifestyle

Is there anything I can do before and after surgery to help keep my erections?

If you have surgery to remove the prostate (radical prostatectomy) there is a risk that you may have problems getting an erection after your treatment. There are things you can do before and after surgery to help avoid this:

Ask your surgeon if they will be able to do a nerve-sparing prostatectomy. There are two bundles of nerves that control erections on either side of the prostate. Saving these nerves during surgery increases the chances of keeping erections afterwards. However, nerve-sparing surgery is only suitable if your cancer has not spread outside of the prostate. And, sometimes the nerves can only be saved on one side. Even if your surgeon does save the nerves, you may still have problems getting an erection.

The likelihood of having erection problems depends on several things such as your age, the strength of your erections before surgery, other medical conditions such as high blood pressure or diabetes, and whether you smoke.1,2

At first, most men find it difficult to get an erection strong enough for sexual intercourse and it can take anything from a few months to three years for erections to return.3 Erections are often not as good as they were before surgery and some men will never get back the ability to maintain an erection without the help of artificial methods such as vacuum pumps or tablets.4

There are treatments available to help with erection problems. These include tablets called PDE5 inhibitors (brand names: Viagra®, Cialis® or Levitra®), vacuum pumps, injections and pellets. You will not be prescribed PDE5 inhibitors if you are taking medicines called nitrates for a heart problem. Your doctor may refer you to an erectile dysfunction clinic for treatment and advice for erection problems.

Your doctor may suggest that you start treatments for erection problems in the first few weeks after surgery. Even if you are not ready to start any sexual activity yet, some research suggests that starting treatment soon after surgery may improve your chances of getting erections later on.5,6 You may hear this called penile rehabilitation.

If you are able to get erections you will not be able to ejaculate. This is because the prostate gland and seminal vesicles, which produce the fluid in the semen, are removed during the operation. Instead you may have a 'dry orgasm' where you feel the sensations of orgasm, but do not release any semen from the penis. This may feel different to orgasms you are used to.

You can read more about erection problems following surgery and ways to manage these in our pages about sex and prostate cancer.

Last updated August 2012

To be reviewed August 2014

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How can I manage incontinence when travelling abroad?

Incontinence after prostate cancer treatment could affect your travel plans. This should not stop you from travelling but it might affect where you go and what sort of things you do while you're away. Here are some tips for planning your trip.

If you have urinary problems and use pads, make sure you pack enough for your trip and a few extra in case of delays.

  •  Pack extra pads and medicine in your hand luggage in case your suitcase gets lost.

If you use a catheter:

  • take a spare catheter with you
  • take plenty of extra drainage bags or catheter valves
  • speak to your specialist nurse about caring for your catheter while you are away
  • ask your doctor for a letter that explains what your equipment is for. This is called a medical validation certificate and it might make things easier if customs officials decide to search your bag.


Tell your travel company about any special needs you have. They may be able to help or give you a seat close to the toilet.

Find out how you can have your clothes washed if needed at your destination.

If you are worried about leaking during the night, ask your hotel or accommodation if they can provide a protective sheet for the bed.

Drink a little less while you are on holiday but take care to stay hydrated, especially if it is hot weather.

Read more about travelling with prostate cancer.

Last updated January 2013

To be reviewed January 2015

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Advanced cancer

Where does prostate cancer spread to?

If prostate cancer spreads outside of the prostate it can spread to the area just outside of the prostate or to other parts of the body, such as the bones.

Locally advanced prostate cancer

Locally advanced prostate cancer is cancer that is starting to break out of the prostate, or has spread to the area just outside the prostate, and may also affect the seminal vesicles, pelvic lymph nodes, neck of the bladder or back passage.

The seminal vesicles are two glands situated behind the prostate which produce some of the fluid in semen. The lymph nodes are part of the immune system. There are lymph nodes in the groin and pelvic area, near the prostate called the pelvic lymph nodes.

For more information, read our pages about locally advanced prostate cancer.

Advanced prostate cancer

Advanced prostate cancer is cancer that has spread from the prostate gland to other parts of the body. It is also called metastatic prostate cancer. This is when tiny prostate cancer cells move from the prostate to other parts of the body through the blood stream or lymphatic system.

Prostate cancer can spread to any part of the body but it most commonly spreads to the bones and the lymph nodes (sometimes called lymph glands). More than four out of five men (80 per cent) with advanced prostate cancer will have cancer that has spread to the bones.  The lymph nodes are part of the body's immune system and carry fluid called lymph around the body. There are lymph nodes throughout the body, including in the groin and pelvic area, near the prostate.

For more information, read our pages about advanced prostate cancer.

Staging

Staging is a way of recording how far the cancer may have spread. The most common method is the TNM (Tumour-Nodes-Metastases) system. This looks at the tumour (T), lymph nodes (N) and whether the cancer has spread to other parts of the body or metastasised (M).

Read more about:

Updated July 2012

To be reviewed July 2014

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What causes lympheodema and how can I stop the swelling?

Lymphoedema is caused by a blockage in part of the body's immune system called the lymphatic system. This causes fluid to build up in the body's tissues, causing swelling. This is lymphoedema. 

Some of the lymph nodes are in the groin and pelvic area - near the prostate. The cancer might spread to the lymph nodes or to surrounding tissues and press on the lymph vessels. Treatments for prostate cancer can also affect the lymphatic system. You may be at greater risk of lymphoedema if you have had surgery or radiotherapy to the lymph nodes. 

What can help?

Speak to your nurse or GP if you have any of the symptoms. Treatments can manage it, although they cannot cure it. They are most effective if started early. You may be referred to a specialist lymphoedema nurse. 

Click here to read about treatments which might help.

 

Updated January 2013

To be reviewed January 2015

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References

What does 'benign enlargement of the prostate' mean?

  1. Trueman P, Hood SC, Nayak USL et al. Prevalence of lower urinary tract symptoms and self-reported diagnosed 'benign prostatic hyperplasia', and their effect on quality of life in a community-based survey of men in the UK. BJU Int 1999; 83: 410-415.
  2. Wei JT, Calhoun E, Jacobsen SJ. Urologic diseases in America project: benign prostatic hyperplasia. Journal of Urology 2005; 173: 1256-1261.


Am I more likely to get prostate cancer if my father had it?

  1. Gene polymorphisms and prostate cancer: the evidence 2009 BJUI: 104 1560-1572..
  2. Elo JP and Visakorpi T. Molecular genetics of prostate cancer. Ann Med 2001;33(2):130-41.
  3. Bandolier Johns LE, Houlston RS. A systematic review and meta-analysis of familial prostate cancer risk. BJU International 2003; 91: 789-794.


Is it true that African Caribbean men are more likely to get prostate cancer?

  1. Ben-Shlomo Y, Evans S, Ibrahim F, Patel B, Anson K, Chinegwundoh F, Corbishley C, Dorling D, Thomas B, Gillatt D, Kirby R, Muir G, Nargund V, Popert R, Metcalfe C, Persad R; PROCESS study group., The Risk of Prostate Cancer amongst Black men in the United Kingdom: The PROCESS Cohort Study, European Urology 53 (2008) 99-105
  2. Xu J, Kibel AS, Hu JJ, Turner AR, Pruett K, Zheng SL, Sun J, Isaacs SD, Wiley KE, Kim ST, Hsu FC, Wu W, Torti FM, Walsh PC, Chang BL, Isaacs WB.Prostate cancer risk associated loci in African Americans Cancer Epidemiol Markers Prev 2009; 18(7) 2145-49).
  3. Hooker S, Hernandez W, Chen H, Robbins C, Torres JB, Ahaghotu C, Carpten J, Kittles RA.Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans Prostate 2010 Feb 15;70(3):270-6).
  4. Wang Y, Ray AM, Johnson EK, Zuhlke KA, Cooney KA, Lange EM. Evidence for an association between prostate cancer and chromosome 8q24 and 10q11 genetic variants in African American men: The flint men's health study† Prostate 2010 Aug 17).
  5. Lavender NA, Benford ML, VanCleave TT, Brock GN, Kittles RA, Moore JH, Hein DW, Kidd LC.Examination of polymorphic glutathione S-transferase (GST) genes, tobacco smoking and prostate cancer risk among Men of African Descent: A case-control study BMC Cancer 2009 9: 397)
  6. Mason TE, Ricks-Santi L, Chen W, Apprey V, Joykutty J, Ahaghotu C, Kittles R, Bonney G, Dunston GM.Association of CD14 variant with prostate cancer in African American men Prostate 2010 Feb 15;70(3):262-9)

Is there anything I can do to prevent getting prostate cancer?

  1. Ho T, Gerber L, Aronson WJ, Terris MK, Presti JC, Kane CJ, Amling CL, Freedland SJ. Obesity, Prostate-Specific Antigen Nadir, and Biochemical Recurrence After Radical Prostatectomy: Biology or Technique? Results from the SEARCH Database European Urology, Available online 20 August 2012
  2. Cao Y. Ma J. Body mass index, prostate cancer-specific mortality, and biochemical recurrence: a systematic review and meta-analysis. [Review] Cancer Prevention Research. 2011; 4(4):486-501
  3. Discacciati A, Orsini N, Wolk A.Body mass index and incidence of localized and advanced prostate cancer--a dose-response meta-analysis of prospective studies. Ann Oncol. 2012 Jul;23(7):1665-71
  4. Häggström C, Stocks T, Ulmert D, Bjørge T, Ulmer H, Hallmans G, Manjer J, Engeland A, Nagel G, Almqvist M, Selmer R, Concin H, Tretli S, Jonsson H, Stattin P. Prospective study on metabolic factors and risk of prostate cancer. Cancer. 2012 Advanced online publication
  5. World Cancer Research Fund/American Institute for Cancer. Food, Nutrition, Physical Activity and the Prevention of Cancer: A Global Perspective. Washington DC:AICR, 2007

Do vitamin E and selenium protect against prostate cancer?

  1. Klein EA, Thompson IA, Tangen CM et al. Vitamin E and the Risk of Prostate Cancer. The Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA. 2011;306(14):1549-1556.
  2. Hurst R, Hooper L, Norat T, Lau R, Aune D, Greenwood DC, Vieira R, Collings R, Harvey LJ, Sterne JA, Beynon R, Savovic J, Fairweather-Tait SJ.Selenium and prostate cancer: systematic review and meta-analysis. Am J Clin Nutr. 2012: 96(1):111-22. Epub 2012 May 30.
  3. Dennert G, Zwahlen M, Brinkman M, Vinceti M, Zeegers MPA, Horneber M. Selenium for preventing cancer. Cochrane Database of Systematic Reviews 2011, Issue 5. Art. No.: CD005195. DOI: 10.1002/14651858.CD005195.pub2.

Does drinking alcohol increase my risk of getting prostate cancer?

  1. Rota M, Scotti L, Turati F, Tramacere I, Islami F, Bellocco R, Negri E, Corrao G, Boffetta P, La Vecchia C, Bagnardi V. Alcohol consumption and prostate cancer risk: a meta-analysis of the dose-risk relation. Eur J Cancer Prev. 2012 Jul;21(4):350-9.
  2. NHS Choices. Effects of alcohol. Available from: http://www.nhs.uk/Livewell/alcohol/Pages/Effectsofalcohol.aspx. Accessed September 2012

Does red wine help to prevent prostate cancer?

  1. Schoonen WM, Salinas CA, Kiemeney LALM, Stanford JL. Alcohol consumption and risk of prostate cancer in middle-aged men. Int. J. Cancer. 2005 Jan 1;113(1):133-40.
  2. Chao C, Haque R, Van Den Eeden SK, Caan BJ, Poon K-YT, Quinn VP. Red wine consumption and risk of prostate cancer: the California men's health study. Int. J. Cancer. 2010 Jan 1;126(1):171-9.
  3. Sutcliffe S, Giovannucci E, Leitzmann MF, Rimm EB, Stampfer MJ, Willett WC, et al. A prospective cohort study of red wine consumption and risk of prostate cancer. Int. J. Cancer. 2007 Apr 1;120(7):1529-35.
  4. Rota M, Scotti L, Turati F, Tramacere I, Islami F, Bellocco R, et al. Alcohol consumption and prostate cancer risk: a meta-analysis of the dose-risk relation. Eur. J. Cancer Prev. 2012 Jul;21(4):350-9.
  5. Middleton Fillmore K, Chikritzhs T, Stockwell T, Bostrom A, Pascal R. Alcohol use and prostate cancer: a meta-analysis. Mol Nutr Food Res. 2009 Feb;53(2):240-55.
  6. Rizos C, Papassava M, Golias C, Charalabopoulos K. Alcohol consumption and prostate cancer: a mini review. Exp. Oncol. 2010 Jul;32(2):66-70.
  7. The risks of drinking too much - Live Well - NHS Choices [Internet]. [cited 2013 Jan 28]. Available from: http://www.nhs.uk/Livewell/alcohol/Pages/Effectsofalcohol.aspx
  8. Preventing stroke | Stroke Association [Internet]. [cited 2013 Mar 14]. Available from: http://www.stroke.org.uk/about/preventing-stroke

Why is there no screening programme for prostate cancer?

  1. Prostate Cancer Risk Management Programme information for primary care; PSA testing in asymptomatic men. Evidence document January 2010.
  2. Mitra A., Bancroft E, Barbachano Y et al. Targeted prostate cancer screening in men with mutations in BRCA1 and BRCA2 detects aggressive prostate cancer: preliminary analysis of the results of the IMPACT study. BJUI 2010; 107: 28-39.

Can you tell me more about the PCA3 test?

  1. Schilling D, de Reijke T, Tombal B, de la Taille A, Hennenlotter J, Stenzl A. The Prostate Cancer gene 3 assay: indications for use in clinical practice. BJU I 2009 105, 452-455
  2. Schilling D, de Reijke T, Tombal B, de la Taille A, Hennenlotter J, Stenzl A Follow-up of men with an elevated PCA3 score and a negative biopsy: does an elevated PCA3 score indeed predict the presence of prostate cancer? BJU Int. 2010 Feb;105(4):452-5.
  3. Noguerira L, Corradi R, Eastham J. Other biomarkers for detecting prostate cancer. BJUI 2009 105, 166-169

What does 'Gleason score' mean?

  1. Berney, D M (2007). The case for modifying the Gleason grading system. BJU Int, 100 (4), p.725-726

How will I know ifmy cancer is spreading if I am having active aurveillance?

  1. Parker, C and O'Donnell H. Treatment of early prostate cancer: active surveillance. Trends in Urology Gynaecology & Sexual Health May/June 2009

Is robotic surgery better than surgery by hand?

  1. Heidenreich A, Bolla M, Joniau S et al. 2011. Guidelines on prostate cancer. European Association of Urology.

How can I find out if my consultant is a good surgeon?

  1. Vesey SG, McCabe JE, Hounsome L & Fowler S. UK radical prostatectomy outcomes and surgeon case volume: based on an analysis of the British Association of Urological Surgeons Complex Operations Database. BJU International. 2011;109:346-354.
  2. National Institute for Clinical Excellence. 2002. Improving outcomes in urological cancers: the manual. London: National Institute for Clinical Excellence.

How do oestrogens treat prostate cancer?

  1. British National Formulary www.bnf.org.uk accessed August 2010
  2. Burns-Cox N, Basketter V, Higgins B, Holmes S. Prospective randomized trial comparing diethylstilboestrol and flutamide in the treatment of hormone relapsed prostate cancer. International Journal of Urology 2002; 9(8): 431-434

What is abiraterone?

  1. De Bono JS, Logothetis Cj, Molina A et al. Abiraterone and increased survival in metastatic prostate cancer. The New England Journal of Medicine. 2011;364(21):1995-2005.
  2. Ryan CJ, Smith MR, de Bono JS et al. Interim analysis (IA) results of COU-AA-302, a randomized, phase 3 study of abiraterone acetate (AA) in chemotherapy-naïve patients (pts) with metastatic castration-resistant prostate cancer (mCRPC). Available at: http://www.urotoday.com/Treatment-of-mCRPC/asco-2012-interim-analysis-ia-results-of-cou-aa-302-a-randomized-phase-3-study-of-abiraterone-acetate-aa-in-chemotherapy-naive-patients-pts-with-metastatic-castration-resistant-slid.html (accessed August 2012).

How can I get an erection after treatment?

  1. Mulhall JP. Saving your Sex Life; a guide for men with prostate cancer.
  2. Segenreich E, Israilov SR, Shmueli J, Servadio C. Vacuum therapy combined with psychotherapy for management of severe erectile dysfunction. Eur Urol. 1995;28:47-50.
  3. Rosen RC. Erectile dysfunction: the medicalization of male sexuality. Clin Psychol Rev. 1996;16:497-519.
  4. Titta M, Tavolini IM, Moro FD, Cisternino A, Bassi P. Sexual counselling improved erectile rehabilitation after non-nerve-sparing radical retropubic prostatectomy or cystectomy - results of a randomized prospective study. J Sex Med 2006;3:267.

When will I stop leaking urine after surgery?

  1. MacDonald R, Fink HA, Huckabay C et al. Pelvic floor muscle training to improve urinary incontinence after radical prostatectomy: a systematic review of effectiveness. BJU Int. 2007; 100(1): 76-81.
  2. Hunter KF, Moore KN, Glazener CMA. Conservative management for postprostatectomy urinary incontinence. Cochrane Database of Systematic Reviews 2007, Issue 2.
  3. National Institute for Health and Clinical Excellence. 2010. Lower urinary tract symptoms: The management of lower urinary tract symptoms in men. London: National Institute for Health and Clinical Excellence.

Does stopping hormone therapy from time to time help to reduce the side effects?

  1. Abrahamsson P. Potential Benefits of Intermittent Androgen Suppression Therapy in the Treatment of Prostate Cancer: A Systematic Review of the Literature. European Urology, 57 (1): 49-59.

How can I manage hot flushes?

  1. Heidenreich A, Bolla M, Joniau S et al. Guidelines on prostate cancer. European Association of Urology. 2010

Is there anything I can do before and after surgery to help keep my erections?

  1. Briganti A, Capitanio U, Chun FK-H, et al. Prediction of Sexual Function After Radical Prostatectomy. Cancer. 2009. DOI: 10.1002/cncr.24349,
  2. Mulhall JP. Defining and reporting erectile function outcomes after radical prostatectomy: challenges and misconceptions. J. Urol. 2009; 181: 462-471.
  3. Abdollah F, Sun M, Suardi N et al. Prediction of functional outcomes after nerve-sparing radical prostatectomy: Results of conditional survival analyses. European Urology. 2012. Doi:10.1016/j.eururo.2012.02.057
  4. Levinson AW, Lavery HJ, Ward NT et al. Is a return to baseline sexual function possible? An analysis of sexual function outcomes following laparoscopic radical prostatectomy. World J Urol (2011) 29:29-34
  5. Garcia FJ & Brock G. Current state of penile rehabilitation after radical prostatectomy. Current Opinion in Urology. 2010;20:234-240.
  6. Magheli A & Burnett AL. Erectile dysfunction following prostatectomy: prevention and treatment. Nature Reviews Urology. 2009;6:415-427.